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KMID : 0365819730130010139
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Journal of Pusan Medical College
1973 Volume.13 No. 1 p.139 ~ p.148
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Effects of Ethanol on Glucose Tolerance and Insulia Response
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Abstract
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This study was carried out to investigate the effects of ethanol on the glucose tolerance and insulin response as well as the potassium level of blood in rabbits. The experimental animals fasted for 43 hours or more were divided into three groups. The group A was given ethanol alone (1gm/kg b. w. ), the group B glucose alone (1gm/kg b. w. ), and the group C both ethanol (0. 5gm/kg b. w.) and glucose (igm/kg b. w. ). The test substances were dissolved in water to make 3 ml of solution before administration. Each solution was given by means of a rubber catheter into the stomach. The plasma glucose, plasma insulin and serum potassium concentrations were determined before and after 15, 30, 60, 90 and 120 minutes after the administration of each test solution. The plasma glucose was determined by Somogi method, plasma insulin by double antibody radioimmunoassay and serum potassium by atomic absorption spectrophotometer.
The results obtained were as follows:
1. In the fasted rabbits given ethanol alone the plasma glucose and insulin concentrations showed no significant change after the administration of the test solution.
2. In the fasted rabbits given glucose alone the plasma glucose and insulin concentrations increased up to 60 minutes to reach their peak values, and then decreased acutely to normal level.
3. In the fasted rabbits given ethanol and glucose at the same time the plasma glucose concentration increased up to 60 minutes just as it did in the rabbits given glucose alone, and thereafter, instead of decreasing, continued to increase up to 90 minutes after the administration of the test solution to reach its peal: value and then returned to normal level.
The increase of plasma insulin concentration in these rabbits was immediate and more marked and prolonged than that in the rabbits given glucose alone, reaching its peak value at 90 minutes after the administration of the test solution.
4. In the fasted rabbits given ethanol alone, glucose alone or both ethanol and glucose the serum potassium concentration showed little change.
In the discussion of the results the author suggested that the sparing action of the ethanol to glucose might be responsible for the decreased glucose tolerance despite of the accelerated insulin response in the rabbits given both ethanol and glucose.
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